Internship in Translational Pharmacokinetics/Pharmacodynamics Modeling of Oligonucleotides (starting July 2025 or upon availability, for 6 months)

At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections,  where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters.

The Position

At Roche, we believe it’s urgent to deliver medical solutions right now – even as we develop innovations for the future. We are passionate about transforming patients’ lives, and we are fearless in both making decisions and taking action. And we believe that good business means a better world.

That is why we come to work each day. We commit ourselves to scientific rigor, unassailable ethics, and access to medical innovations for all. We do this today to build a better tomorrow.

At Translational PK/PD and Clinical Pharmacology (TPCP), we drive benefits to every patient by selecting the right drug and dosing regimen. During drug discovery, one of our key activities is estimating efficacious dose in humans using the non-clinical data—which serves as an early assessment drug feasibility and informs the clinical development programs.

In this position, you will

• Learn and apply pharmacokinetics-pharmacodynamics models of therapeutic oligonucleotides to understand the drug concentrations and the drug effect in non-clinical studies 
• Evaluate and compare different translational methods to identify a robust method(s) for estimating efficacious dose in humans
• Be part of a 3-4 team focusing on discovery of therapeutic oligonucleotides under the co-supervision of a team leader and cross-functional team members
• Be exposed to novel therapeutic approaches to improve quality of life for patients living with chronic, severe diseases

Who you are

You are currently enrolled in a university B.Sc. or M.Sc. program in life sciences (preferably in the area of Pharmacology, Biomedical Sciences/Engineering, or a related discipline) or you have completed your degree within the past 12 months

Moreover, you are

• Ideally trained and experienced in mathematical modeling of biological systems or pharmacokinetics/pharmacodynamics modeling, with an understanding of ordinary differential equations
• Familiar with Matlab, R, Phoenix Nonlin, NONMEM, or a similar software

To be considered, please send us your complete application merged into one PDF including

• CV
• Motivation letter (including desired start date & duration)
• A certificate of enrollment (if you are currently studying)
• For Non-EU/EFTA citizens: Due to regulations, you must provide a letter from your university stating that an internship is mandatory for your studies. Please upload this letter, along with your enrollment certificate, CV, and motivation letter.

Planned Start Date: July 2025 or upon availability

Workload: 100%

Duration: 6 months

For more information about opportunities for students and graduates, visit genext.roche.com

If you still have questions, then please check our FAQs and videos on https://careers.roche.com/global/en/faq

Tags: PK/PD models, oligonucleotides, siRNA, and human dose prediction, mathematical models

Who we are

A healthier future drives us to innovate. Together, more than 100’000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life-changing healthcare solutions that make a global impact.

Let’s build a healthier future, together.

Roche is an Equal Opportunity Employer.